The 3.2 hectare Grampians Estate vineyard grows shiraz and chardonnay. The first 1.6 hectares of vines were planted in 1989. In 1994 a group of friends banded together to create Grampians Estate Wine Company to further develop the vineyard and commence Grampians wine production.

Vintages of Australian shiraz and chardonnay ensued from 1995, the quality and quantity of which gradually improved as vineyard management and industry knowledge grew. In 2004 Tom and Sarah Guthrie bought out the company and today continue to build on the great achievements of those years.

The Grampians Estate wine label is significant for a variety of reasons. It features the classic Australian painting Land of the Golden Fleece by Sir Arthur Streeton with Major Mitchell Plateau, the highest part of the Grampians apart from Mount William, overlooking a typical Australian landscape. Streeton, a member of the famous Heidelberg School of painters, referred to this 1926 painting as his greatest work.

The Grampians Estate vineyard is located on the north side of the Muirhead Range in front of the Plateau, whilst the painting itself was painted from Yarram Park, a neighbouring property where Sarah Guthrie grew up.